Mark W. Irvine

Bristol, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators.

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators.

Journal: Neuropharmacology

Published: July 20, 2021

Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.

Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.

Journal: Neuropharmacology

Published: May 15, 2021

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.

Journal: Nature communications

Published: October 07, 2019

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.

Journal: European journal of medicinal chemistry

Published: October 17, 2018

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.

Journal: Biochemical pharmacology

Published: October 02, 2018

Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.

Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.

Journal: Journal of medicinal chemistry

Published: February 16, 2018

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

Journal: Neuropharmacology

Published: March 29, 2017

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

Journal: Scientific reports

Published: December 02, 2016

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.

Journal: The Journal of biological chemistry

Published: November 14, 2016

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.

Journal: Neuropharmacology

Published: July 18, 2016

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.

Journal: Synthesis

Published: November 17, 2015

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.

Journal: Hippocampus

Published: March 17, 2015

Showing 1-12 of 17

Last Updated: 09/26/2026