Markus G. Rudolph

Basel, BS 4070, Switzerland

Last Updated: 09/26/2026

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Found 41 publications

Structure-Based Design of Potent TLR7/8/9 Triple Antagonists: Overcoming High Tissue Distribution and Reactive Metabolite Liabilities.

Structure-Based Design of Potent TLR7/8/9 Triple Antagonists: Overcoming High Tissue Distribution and Reactive Metabolite Liabilities.

Journal: Journal of medicinal chemistry

Published: July 22, 2026

New structures of human formylglycine-generating enzyme reveal features important for catalysis, disease and structure-based drug design.

New structures of human formylglycine-generating enzyme reveal features important for catalysis, disease and structure-based drug design.

Journal: Journal of molecular biology

Published: February 18, 2026

The CASP 16 Experimental Protein-Ligand Datasets.

The CASP 16 Experimental Protein-Ligand Datasets.

Journal: Proteins

Published: April 25, 2025

A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding.

A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding.

Journal: Acta crystallographica. Section D, Structural biology

Published: April 15, 2025

A high-resolution data set of fatty acid-binding protein structures. II. Crystallographic overview, ligand classes and binding pose.

A high-resolution data set of fatty acid-binding protein structures. II. Crystallographic overview, ligand classes and binding pose.

Journal: Acta crystallographica. Section D, Structural biology

Published: April 09, 2025

A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands.

A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands.

Journal: Acta crystallographica. Section D, Structural biology

Published: April 09, 2025

Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode.

Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode.

Journal: Bioorganic & medicinal chemistry letters

Published: December 11, 2024

Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

Journal: Nature

Published: July 03, 2024

Discovery of Orally Available and Brain Penetrant AEP Inhibitors.

Discovery of Orally Available and Brain Penetrant AEP Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 13, 2023

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.

Journal: Nature

Published: October 19, 2023

Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.

Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.

Journal: ACS medicinal chemistry letters

Published: May 04, 2023

Details Matter in Structure-based Drug Design.

Details Matter in Structure-based Drug Design.

Journal: Chimia

Published: April 25, 2023

Showing 1-12 of 41

Last Updated: 09/26/2026