Markus Wartmann

Basel, BS 4002, Switzerland

Last Updated: 09/26/2026

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Found 25 publications

Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter.

Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter.

Journal: Journal of medicinal chemistry

Published: March 04, 2026

Fragment-based discovery enables direct targeting of the melanoma oncogene MITF.

Fragment-based discovery enables direct targeting of the melanoma oncogene MITF.

Journal: Nature communications

Published: November 10, 2024

Author Correction: Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.

Author Correction: Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.

Journal: Nature cancer

Published: June 17, 2024

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

Journal: Nature

Published: July 26, 2023

Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.

Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.

Journal: Nature cancer

Published: May 22, 2023

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.

Journal: ChemMedChem

Published: February 01, 2023

Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.

Time matters - in vitro cellular disposition kinetics help rationalizing cellular potency disconnects.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: October 03, 2022

INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.

INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.

Journal: Nature cancer

Published: July 25, 2022

The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.

The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.

Journal: ChemMedChem

Published: June 01, 2022

Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.

Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.

Journal: Journal of medicinal chemistry

Published: May 02, 2022

A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues.

A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues.

Journal: Frontiers in pharmacology

Published: September 29, 2021

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

Journal: Journal of medicinal chemistry

Published: November 30, 2020

Showing 1-12 of 25

Last Updated: 09/26/2026