Last Updated: 09/26/2026
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Found 12 publications
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
Journal: Journal of medicinal chemistry
Published: June 10, 2021
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
Journal: Journal of medicinal chemistry
Published: December 28, 2020
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Journal: Cancer cell
Published: November 02, 2020
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Journal: The Journal of biological chemistry
Published: October 28, 2020
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Journal: Journal of medicinal chemistry
Published: December 13, 2016
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Journal: Journal of medicinal chemistry
Published: August 12, 2016
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
Journal: Journal of medicinal chemistry
Published: January 13, 2016
A simple litmus test for aldehyde oxidase metabolism of heteroarenes.
Journal: Journal of medicinal chemistry
Published: January 30, 2014
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Journal: Bioorganic & medicinal chemistry letters
Published: February 04, 2013
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters
Published: December 14, 2011
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer.
Journal: Bioorganic & medicinal chemistry letters
Published: October 13, 2011
Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO).
Journal: Journal of medicinal chemistry
Published: September 30, 2011
Showing 1-12 of 12
Last Updated: 09/26/2026