Martin P. Edwards

Radiology | Interventional Radiology

1401 S Grand Ave
C/O Radiology
Los Angeles, CA 90015

Last Updated: 09/26/2026

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Found 20 publications

Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor.

Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor.

Journal: Journal of medicinal chemistry

Published: December 05, 2025

Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.

Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.

Journal: Journal of medicinal chemistry

Published: December 09, 2024

An update on lipophilic efficiency as an important metric in drug design.

An update on lipophilic efficiency as an important metric in drug design.

Journal: Expert opinion on drug discovery

Published: June 26, 2024

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.

Journal: Journal of medicinal chemistry

Published: March 20, 2023

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Journal: Journal of medicinal chemistry

Published: December 28, 2020

Salvage of renal transplant with vacuum-assisted thrombectomy of large iliocaval and allograft venous outflow thrombus.

Salvage of renal transplant with vacuum-assisted thrombectomy of large iliocaval and allograft venous outflow thrombus.

Journal: Diagnostic and interventional radiology (Ankara, Turkey)

Published: May 08, 2019

Intervention in Massive Pulmonary Embolus: Catheter Thrombectomy/Thromboaspiration versus Systemic Lysis versus Surgical Thrombectomy.

Intervention in Massive Pulmonary Embolus: Catheter Thrombectomy/Thromboaspiration versus Systemic Lysis versus Surgical Thrombectomy.

Journal: Seminars in interventional radiology

Published: June 07, 2018

Lipophilic Efficiency as an Important Metric in Drug Design.

Lipophilic Efficiency as an Important Metric in Drug Design.

Journal: Journal of medicinal chemistry

Published: March 29, 2018

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).

Journal: Journal of medicinal chemistry

Published: December 07, 2017

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Journal: Journal of medicinal chemistry

Published: March 14, 2017

Transulnar approach as an alternative to transradial approach in non-coronary intervention: safety, feasibility and technical factors.

Transulnar approach as an alternative to transradial approach in non-coronary intervention: safety, feasibility and technical factors.

Journal: The journal of vascular access

Published: January 05, 2017

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 13, 2016

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Last Updated: 09/26/2026