Martina Hrast

Ljubljana, Slovenia

Last Updated: 09/26/2026

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Found 46 publications

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening.

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening.

Journal: Chembiochem : a European journal of chemical biology

Published: March 27, 2026

Auger Shake-Up Assisted Electron Recapture.

Auger Shake-Up Assisted Electron Recapture.

Journal: Physical review letters

Published: May 17, 2023

Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions.

Exploring Alternative Pathways to Target Bacterial Type II Topoisomerases Using NBTI Antibacterials: Beyond Halogen-Bonding Interactions.

Journal: Antibiotics (Basel, Switzerland)

Published: March 27, 2023

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis.

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: November 29, 2022

Design and Preparation of Antimicrobial Agents.

Design and Preparation of Antimicrobial Agents.

Journal: Antibiotics (Basel, Switzerland)

Published: November 23, 2022

Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.

Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy.

Journal: European journal of medicinal chemistry

Published: November 07, 2022

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors.

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: November 01, 2022

Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?

Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?

Journal: ACS medicinal chemistry letters

Published: September 23, 2022

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.

Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.

Journal: European journal of medicinal chemistry

Published: June 22, 2022

DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway.

DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway.

Journal: Bioorganic & medicinal chemistry letters

Published: June 07, 2022

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.

Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations.

Journal: Bioorganic chemistry

Published: May 20, 2022

Screening of Big Pharma's Library against Various in-house Biological Targets.

Screening of Big Pharma's Library against Various in-house Biological Targets.

Journal: Molecules (Basel, Switzerland)

Published: May 18, 2022

Showing 1-12 of 46

Last Updated: 09/26/2026