Masakazu Atobe

Izunokuni, 4102321, Japan

Last Updated: 09/26/2026

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Found 16 publications

α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.

α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping.

Journal: Angewandte Chemie (International ed. in English)

Published: September 26, 2023

Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.

Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.

Journal: RSC medicinal chemistry

Published: July 22, 2022

Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy.

Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy.

Journal: Journal of medicinal chemistry

Published: June 20, 2020

Design and Synthesis of 56 Shape-Diverse 3D Fragments.

Design and Synthesis of 56 Shape-Diverse 3D Fragments.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: March 04, 2020

Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis.

Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis.

Journal: Current topics in medicinal chemistry

Published: June 18, 2019

Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.

Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.

Journal: Journal of medicinal chemistry

Published: January 11, 2019

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model.

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model.

Journal: Bioorganic & medicinal chemistry letters

Published: April 13, 2018

A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.

A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.

Journal: Bioorganic & medicinal chemistry letters

Published: August 09, 2017

Increase of enzyme activity through specific covalent modification with fragments.

Increase of enzyme activity through specific covalent modification with fragments.

Journal: Chemical science

Published: May 02, 2017

Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

Journal: Bioorganic & medicinal chemistry

Published: February 09, 2015

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.

Journal: Bioorganic & medicinal chemistry letters

Published: November 05, 2013

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters

Published: September 14, 2013

Showing 1-12 of 16

Last Updated: 09/26/2026