Masami Kusaka
Fujisawa, 2518555, Japan
Last Updated: 09/26/2026
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Found 15 publications
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model.
Journal: European journal of pharmacology
Published: October 17, 2017
A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.
Journal: Bioorganic & medicinal chemistry letters
Published: August 29, 2017
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
Journal: Journal of medicinal chemistry
Published: September 03, 2016
Selective androgen receptor modulator activity of a steroidal antiandrogen TSAA-291 and its cofactor recruitment profile.
Journal: European journal of pharmacology
Published: June 05, 2015
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.
Journal: Bioorganic & medicinal chemistry
Published: February 01, 2015
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
Journal: Journal of medicinal chemistry
Published: June 12, 2014
The effects of chronic subcutaneous administration of an investigational kisspeptin analog, TAK-683, on gonadotropin-releasing hormone pulse generator activity in goats.
Journal: Neuroendocrinology
Published: June 03, 2014
Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.
Journal: European journal of pharmacology
Published: October 13, 2013
Differential effects of continuous exposure to the investigational metastin/kisspeptin analog TAK-683 on pulsatile and surge mode secretion of luteinizing hormone in ovariectomized goats.
Journal: The Journal of reproduction and development
Published: September 20, 2013
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice.
Journal: European journal of pharmacology
Published: August 25, 2013
Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.
Journal: The Journal of steroid biochemistry and molecular biology
Published: January 29, 2013
Last Updated: 09/26/2026