Mathy Froeyen

Leuven, VLG 3000, Belgium

Last Updated: 09/26/2026

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Found 36 publications

Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve.

Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve.

Journal: Bioorganic chemistry
Published: May 07, 2026

Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors.

Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors.

Journal: Frontiers in chemistry
Published: December 30, 2025

Synthesis, structure-activity relationship study and molecular modeling of triazolo[4,5-d]pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors.

Synthesis, structure-activity relationship study and molecular modeling of triazolo[4,5-d]pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors.

Journal: European journal of medicinal chemistry
Published: October 21, 2025

Synthesis and evaluation of isothiazolo[4,5-b]pyridines as cyclin G-associated kinase (GAK) inhibitors.

Synthesis and evaluation of isothiazolo[4,5-b]pyridines as cyclin G-associated kinase (GAK) inhibitors.

Journal: Organic & biomolecular chemistry
Published: August 22, 2024

Impact of sulfur substitution on biotin binding affinity to streptavidin.

Impact of sulfur substitution on biotin binding affinity to streptavidin.

Journal: Bioorganic chemistry
Published: May 16, 2024

Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase.

Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-b]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase.

Journal: Molecules (Basel, Switzerland)
Published: January 15, 2024

Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline.

Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline.

Journal: Nucleic acids research
Published: September 22, 2023

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species.

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species.

Journal: Antiviral research
Published: June 23, 2021

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

Journal: European journal of medicinal chemistry
Published: October 22, 2020

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.

Journal: Journal of enzyme inhibition and medicinal chemistry
Published: December 12, 2019

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.

Journal: Nucleic acids research
Published: November 13, 2019

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.

Journal: Bioorganic & medicinal chemistry
Published: August 28, 2019
Showing 1-12 of 36

Last Updated: 09/26/2026