Matilda Katan

London, ENG WC1E6BT, United Kingdom

Last Updated: 09/26/2026

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Found 44 publications

Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.

Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.

Journal: The Biochemical journal

Published: July 29, 2025

Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey.

Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey.

Journal: Biochimica et biophysica acta. Molecular and cell biology of lipids

Published: February 23, 2025

Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.

Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.

Journal: Advances in biological regulation

Published: September 09, 2024

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3.

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3.

Journal: Scientific reports

Published: June 16, 2024

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: July 04, 2023

Targeting G-CSF to treat autoinflammation.

Targeting G-CSF to treat autoinflammation.

Journal: Nature immunology

Published: March 30, 2023

A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.

A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: August 03, 2022

Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.

Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.

Journal: Science advances

Published: June 24, 2022

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Journal: Nature

Published: September 17, 2021

Cells of the human intestinal tract mapped across space and time.

Cells of the human intestinal tract mapped across space and time.

Journal: Nature

Published: November 24, 2020

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane.

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane.

Journal: Essays in biochemistry

Published: July 09, 2020

Phospholipase C families: Common themes and versatility in physiology and pathology.

Phospholipase C families: Common themes and versatility in physiology and pathology.

Journal: Progress in lipid research

Published: June 09, 2020

Showing 1-12 of 44

Last Updated: 09/26/2026