Matteo Santucci

Via Campi 103
Modena, 41125, Italy

Last Updated: 09/26/2026

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Found 28 publications

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

Journal: Journal of medicinal chemistry

Published: November 03, 2023

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

Journal: European journal of medicinal chemistry

Published: September 11, 2023

SCFβTrCP-mediated degradation of SHARP1 in triple-negative breast cancer.

SCFβTrCP-mediated degradation of SHARP1 in triple-negative breast cancer.

Journal: Cell death & disease

Published: March 29, 2023

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.

Journal: Journal of medicinal chemistry

Published: June 08, 2022

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library.

Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library.

Journal: Pharmaceutics

Published: November 30, 2021

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: October 31, 2021

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.

Journal: eLife

Published: September 14, 2021

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.

Journal: Cancers

Published: March 19, 2021

Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting.

Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting.

Journal: Journal of medicinal chemistry

Published: March 12, 2021

Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase.

Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase.

Journal: Chembiochem : a European journal of chemical biology

Published: October 19, 2020

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases.

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases.

Journal: Scientific reports

Published: December 19, 2019

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.

Journal: European journal of medicinal chemistry

Published: August 23, 2019

Showing 1-12 of 28

Last Updated: 09/26/2026