Matthew P. Coghlan
Granta Park
Cambridge, ENG, United Kingdom
Cambridge, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 22 publications
Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.
Journal: Science advances
Published: September 04, 2026
GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models.
Journal: Diabetes, obesity & metabolism
Published: September 29, 2025
Data-driven prioritization of high-risk individuals for weight loss interventions.
Journal: Nature medicine
Published: April 04, 2025
Glucose-dependent insulinotropic polypeptide (GIP).
Journal: Molecular metabolism
Published: December 06, 2024
Tirzepatide leads to weight reduction in people with obesity due to MC4R deficiency.
Journal: Nature medicine
Published: November 10, 2024
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Journal: Cell metabolism
Published: March 04, 2024
Structural determinants of dual incretin receptor agonism by tirzepatide.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: March 25, 2022
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.
Journal: Diabetes
Published: February 15, 2021
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.
Journal: The Journal of clinical investigation
Published: November 24, 2020
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: November 12, 2020
Last Updated: 09/26/2026