Last Updated: 09/26/2026
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Found 16 publications
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
Journal: RSC medicinal chemistry
Published: November 13, 2023
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Journal: Bioorganic & medicinal chemistry letters
Published: August 31, 2023
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat.
Journal: Chemical research in toxicology
Published: May 06, 2023
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Journal: Nature chemical biology
Published: January 17, 2023
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Journal: Journal of medicinal chemistry
Published: December 23, 2022
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Journal: Journal of medicinal chemistry
Published: November 02, 2022
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
Journal: Journal of medicinal chemistry
Published: September 10, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
Journal: Journal of medicinal chemistry
Published: August 19, 2020
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Journal: Journal of medicinal chemistry
Published: February 22, 2018
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
Journal: ACS medicinal chemistry letters
Published: November 21, 2017
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Journal: Journal of medicinal chemistry
Published: August 31, 2017
Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
Journal: MedChemComm
Published: October 12, 2016
Last Updated: 09/26/2026