Matthias B. Wittwer

Basel, BS 4070, Switzerland

Last Updated: 09/26/2026

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Found 30 publications

DMPK Considerations for the Development of Covalent Drugs: Insights from an IQ Assessment.

DMPK Considerations for the Development of Covalent Drugs: Insights from an IQ Assessment.

Journal: Journal of medicinal chemistry

Published: April 28, 2026

Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds.

Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: January 28, 2026

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Journal: ACS chemical neuroscience

Published: September 18, 2025

Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists.

Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists.

Journal: Pharmacological research

Published: September 08, 2025

Translational molecular imaging and drug development in multiple sclerosis.

Translational molecular imaging and drug development in multiple sclerosis.

Journal: Theranostics

Published: June 14, 2025

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: March 18, 2025

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses.

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses.

Journal: npj drug discovery

Published: March 13, 2025

Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders.

Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders.

Journal: Expert opinion on drug discovery

Published: February 16, 2025

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.

Journal: Nature communications

Published: January 28, 2025

Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice.

Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice.

Journal: Cell communication and signaling : CCS

Published: January 27, 2025

Radiosynthesis and evaluation of novel 18F labeled PET ligands for imaging monoacylglycerol lipase.

Radiosynthesis and evaluation of novel 18F labeled PET ligands for imaging monoacylglycerol lipase.

Journal: European journal of medicinal chemistry

Published: November 25, 2024

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 03, 2024

Showing 1-12 of 30

Last Updated: 09/26/2026