Matthias Gotte

Edmonton, AB T6G2E1, Canada

Last Updated: 09/26/2026

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Found 79 publications

Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening.

Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening.

Journal: bioRxiv : the preprint server for biology

Published: July 17, 2026

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism.

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism.

Journal: bioRxiv : the preprint server for biology

Published: July 17, 2026

The Q226H Mutation in Avian H5N1 Hemagglutinin Mediates a Path towards Structural Adaptation in Humans.

The Q226H Mutation in Avian H5N1 Hemagglutinin Mediates a Path towards Structural Adaptation in Humans.

Journal: bioRxiv : the preprint server for biology

Published: June 05, 2026

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

Journal: bioRxiv : the preprint server for biology

Published: June 05, 2026

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

Journal: The Journal of biological chemistry

Published: June 03, 2026

1'- and 4'-Cyano Modified Adenosine Analogs Against Prototypic Flavivirus RNA-Dependent RNA Polymerases.

1'- and 4'-Cyano Modified Adenosine Analogs Against Prototypic Flavivirus RNA-Dependent RNA Polymerases.

Journal: Viruses

Published: December 05, 2025

Structural basis for selective remdesivir incorporation by SARS-CoV-2 polymerase, and S759A resistance.

Structural basis for selective remdesivir incorporation by SARS-CoV-2 polymerase, and S759A resistance.

Journal: Research square

Published: November 24, 2025

Access to antivirals for treatment of influenza A(H5N1).

Access to antivirals for treatment of influenza A(H5N1).

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Published: October 06, 2025

Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation.

Preferential remdesivir triphosphate incorporation by SARS-CoV-2 polymerase is altered to ATP by the S759A mutation.

Journal: Communications biology

Published: October 06, 2025

Structural basis for selective remdesivir incorporation by SARS-CoV-2 RNA polymerase, and S759A resistance.

Structural basis for selective remdesivir incorporation by SARS-CoV-2 RNA polymerase, and S759A resistance.

Journal: bioRxiv : the preprint server for biology

Published: September 15, 2025

Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.

Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.

Journal: NAR molecular medicine

Published: September 11, 2025

Novel tricycle expanded purine nucleosides with pan-viral activity.

Novel tricycle expanded purine nucleosides with pan-viral activity.

Journal: Bioorganic & medicinal chemistry

Published: July 28, 2025

Showing 1-12 of 79

Last Updated: 09/26/2026