Matti Lepisto

Inflammation And Autoimmunity, Innovative Medicines, AstraZeneca R&D
Moelndal, O 43183, Sweden

Last Updated: 09/26/2026

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Found 17 publications

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

The effect of AZD9567 vs. prednisolone on glycaemic control in patients with type 2 diabetes mellitus: Results from a phase 2a clinical trial.

Journal: British journal of clinical pharmacology

Published: December 07, 2023

Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.

Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.

Journal: Journal of medicinal chemistry

Published: September 22, 2023

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.

Journal: Journal of medicinal chemistry

Published: August 31, 2021

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.

Journal: The Journal of biological chemistry

Published: April 28, 2020

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.

Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.

Journal: Science advances

Published: March 01, 2020

Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.

Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.

Journal: ACS medicinal chemistry letters

Published: April 05, 2019

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design.

Journal: Journal of medicinal chemistry

Published: August 11, 2018

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.

Journal: Journal of medicinal chemistry

Published: February 10, 2018

Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.

Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant.

Journal: Biomolecular NMR assignments

Published: February 06, 2018

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.

Journal: Journal of medicinal chemistry

Published: September 23, 2017

Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.

Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.

Journal: ACS medicinal chemistry letters

Published: March 31, 2017

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.

Journal: Bioorganic & medicinal chemistry letters

Published: August 12, 2016

Showing 1-12 of 17

Last Updated: 09/26/2026