Melanie Grandits

St. George's University Of London
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 34 publications

An antibody-drug conjugate designed through clone and isotype selection restricts the growth of CSPG4-expressing triple-negative breast cancer.

An antibody-drug conjugate designed through clone and isotype selection restricts the growth of CSPG4-expressing triple-negative breast cancer.

Journal: NPJ precision oncology
Published: August 31, 2025

Tuning antibody stability and function by rational designs of framework mutations.

Tuning antibody stability and function by rational designs of framework mutations.

Journal: mAbs
Published: July 14, 2025

Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality.

Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality.

Journal: mAbs
Published: May 16, 2025

Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review.

Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review.

Journal: Allergy
Published: March 11, 2025

Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production.

Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production.

Journal: mAbs
Published: January 20, 2025

Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors.

Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors.

Journal: Journal for immunotherapy of cancer
Published: January 15, 2025

An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities.

An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities.

Journal: Journal of experimental & clinical cancer research : CR
Published: November 08, 2024

An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer.

An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer.

Journal: Cancer research
Published: August 30, 2024

Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction.

Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction.

Journal: Nature communications
Published: December 09, 2023

Privacy-preserving techniques for decentralized and secure machine learning in drug discovery.

Privacy-preserving techniques for decentralized and secure machine learning in drug discovery.

Journal: Drug discovery today
Published: September 01, 2023

Anti-PD1 therapy outcome can be predicted by pre-therapy IFN-I responsiveness of Teff cells.

Anti-PD1 therapy outcome can be predicted by pre-therapy IFN-I responsiveness of Teff cells.

Journal: Allergy
Published: January 31, 2023

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors.

Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors.

Journal: Breast cancer research : BCR
Published: January 16, 2023
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Last Updated: 09/26/2026