Melanie J. Humphry

Papworth Road, Cambridge Biomedical Campus
Cambridge, ENG CB20BB, United Kingdom

Last Updated: 09/26/2026

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Found 16 publications

Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.

Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.

Journal: Atherosclerosis

Published: August 15, 2023

Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.

Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.

Journal: JCI insight

Published: July 18, 2023

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.

Journal: Cardiovascular research

Published: February 14, 2023

The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.

The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.

Journal: Immunology

Published: April 27, 2022

Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.

Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.

Journal: European journal of immunology

Published: December 20, 2019

IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.

IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.

Journal: Aging cell

Published: July 23, 2018

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

Journal: Immunity

Published: June 12, 2018

A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency.

A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci implicated in nitrogen utilization efficiency.

Journal: BMC genomics

Published: November 22, 2016

Phase calibration target for quantitative phase imaging with ptychography.

Phase calibration target for quantitative phase imaging with ptychography.

Journal: Optics express

Published: May 04, 2016

Quantitative electron phase imaging with high sensitivity and an unlimited field of view.

Quantitative electron phase imaging with high sensitivity and an unlimited field of view.

Journal: Scientific reports

Published: June 24, 2015

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.

Journal: The Journal of biological chemistry

Published: May 28, 2015

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.

Journal: Arteriosclerosis, thrombosis, and vascular biology

Published: February 25, 2015

Showing 1-12 of 16

Last Updated: 09/26/2026