Melanie N. Hug

Basel, BS 4070, Switzerland

Last Updated: 09/26/2026

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Found 16 publications

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 03, 2024

HLA antibody affinity determination: From HLA-specific monoclonal antibodies to donor HLA specific antibodies (DSA) in patient serum.

HLA antibody affinity determination: From HLA-specific monoclonal antibodies to donor HLA specific antibodies (DSA) in patient serum.

Journal: HLA

Published: December 30, 2022

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain.

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain.

Journal: European journal of medicinal chemistry

Published: July 01, 2022

Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.

Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.

Journal: Acta neuropathologica communications

Published: March 15, 2022

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.

Journal: Acta neuropathologica

Published: February 21, 2021

Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.

Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.

Journal: Angewandte Chemie (International ed. in English)

Published: October 15, 2020

Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1.

Reply to Alarcon and Borroto: Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction at SH3.1.

Journal: The Journal of biological chemistry

Published: July 19, 2020

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

Journal: The Journal of biological chemistry

Published: February 05, 2020

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.

Journal: ACS chemical biology

Published: November 20, 2018

Synthetic single domain antibodies for the conformational trapping of membrane proteins.

Synthetic single domain antibodies for the conformational trapping of membrane proteins.

Journal: eLife

Published: December 13, 2017

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Journal: Nature communications

Published: November 08, 2016

SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

Journal: PloS one

Published: August 11, 2016

Showing 1-12 of 16

Last Updated: 09/26/2026