Melissa S. Edwards

Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 38 publications

A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.

A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.

Journal: Scientific reports
Published: August 14, 2025

Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors.

Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors.

Journal: The Journal of clinical investigation
Published: July 07, 2025

Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma.

Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma.

Journal: Nature genetics
Published: April 22, 2025

The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study.

The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study.

Journal: The Lancet. Oncology
Published: May 20, 2024

Comprehensive analysis of constitutional mismatch repair deficiency-associated non-Hodgkin lymphomas in a global cohort.

Comprehensive analysis of constitutional mismatch repair deficiency-associated non-Hodgkin lymphomas in a global cohort.

Journal: Pediatric blood & cancer
Published: April 24, 2024

A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency.

A Validated Highly Sensitive Microsatellite Instability Assay Accurately Identifies Individuals Harboring Biallelic Germline PMS2 Pathogenic Variants in Constitutional Mismatch Repair Deficiency.

Journal: Clinical chemistry
Published: October 03, 2023

Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.

Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.

Journal: The Lancet. Oncology
Published: August 28, 2023

Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition.

Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition.

Journal: NPJ precision oncology
Published: June 28, 2023

Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium.

Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium.

Journal: Cancer discovery
Published: May 15, 2023

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing.

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing.

Journal: bioRxiv : the preprint server for biology
Published: February 24, 2023

DNA mismatch and damage patterns revealed by single-molecule sequencing.

DNA mismatch and damage patterns revealed by single-molecule sequencing.

Journal: Nature
Published: February 19, 2023

Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency.

Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published: February 09, 2023
Showing 1-12 of 38

Last Updated: 09/26/2026