Last Updated: 09/26/2026
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Found 75 publications
Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy.
Journal: Epilepsia open
Published: October 10, 2024
ENX-101, a GABAA receptor α2,3,5-selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models.
Journal: Epilepsia
Published: September 17, 2024
Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats.
Journal: CNS neuroscience & therapeutics
Published: September 04, 2024
Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy: A Phase 2b Randomized Clinical Trial.
Journal: JAMA neurology
Published: October 09, 2023
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.
Journal: Epilepsia open
Published: January 18, 2023
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Journal: Epilepsia
Published: September 07, 2022
Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs.
Journal: The Journal of pharmacology and experimental therapeutics
Published: May 18, 2021
Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam.
Journal: Archives of toxicology
Published: February 08, 2021
Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Published: November 30, 2020
Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial.
Journal: Alzheimer's & dementia (New York, N. Y.)
Published: August 11, 2020
Last Updated: 09/26/2026