Last Updated: 09/26/2026
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Found 9 publications
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Journal: Journal of medicinal chemistry
Published: September 12, 2018
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Journal: ACS medicinal chemistry letters
Published: June 27, 2018
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Journal: Journal of medicinal chemistry
Published: June 02, 2018
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Journal: Analytical biochemistry
Published: November 22, 2017
Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.
Journal: Molecular cancer therapeutics
Published: July 12, 2017
Pembrolizumab for the treatment of advanced melanoma.
Journal: Expert opinion on orphan drugs
Published: September 07, 2016
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: February 20, 2014
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Journal: Angewandte Chemie (International ed. in English)
Published: February 17, 2012
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Last Updated: 09/26/2026