Michael D. Flower

UCL Queen Square Institute Of Neurology
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 26 publications

Genetic or pharmacological disruption of the MSH3 Y245/K246 IDL binding pocket slows CAG repeat expansion.

Genetic or pharmacological disruption of the MSH3 Y245/K246 IDL binding pocket slows CAG repeat expansion.

Journal: NAR molecular medicine
Published: February 25, 2026

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Journal: bioRxiv : the preprint server for biology
Published: October 01, 2025

The breaking point where repeat expansion triggers neuronal collapse in Huntington's disease.

The breaking point where repeat expansion triggers neuronal collapse in Huntington's disease.

Journal: Cell genomics
Published: February 21, 2025

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Journal: Science translational medicine
Published: February 12, 2025

Huntington's disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration.

Huntington's disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration.

Journal: Journal of neurology, neurosurgery, and psychiatry
Published: February 26, 2024

Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease.

Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease.

Journal: American journal of human genetics
Published: November 30, 2023

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons.

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons.

Journal: Cell reports
Published: June 21, 2023

Genetic modifiers of repeat expansion disorders.

Genetic modifiers of repeat expansion disorders.

Journal: Emerging topics in life sciences
Published: May 19, 2023

PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease.

PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease.

Journal: Progress in neurobiology
Published: September 05, 2022

Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease.

Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease.

Journal: Brain communications
Published: April 04, 2022

Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues.

Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues.

Journal: Genome biology
Published: February 14, 2022

Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities.

Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities.

Journal: The Lancet. Neurology
Published: September 17, 2021
Showing 1-12 of 26

Last Updated: 09/26/2026