Michael Desgagne

Sherbrooke, QC, Canada

Last Updated: 09/26/2026

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Found 15 publications

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: March 05, 2026

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6.

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6.

Journal: Journal of medicinal chemistry

Published: December 05, 2025

Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.

Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.

Journal: Bioorganic chemistry

Published: October 22, 2024

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

Journal: Pharmacological research

Published: August 23, 2024

Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.

Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.

Journal: Journal of medicinal chemistry

Published: July 19, 2024

Multitarget ligands that comprise opioid/nonopioid pharmacophores for pain management: Current state of the science.

Multitarget ligands that comprise opioid/nonopioid pharmacophores for pain management: Current state of the science.

Journal: Pharmacological research

Published: July 04, 2024

Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics.

Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics.

Journal: Angewandte Chemie (International ed. in English)

Published: March 27, 2024

Insights on Structure-Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles.

Insights on Structure-Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles.

Journal: Journal of medicinal chemistry

Published: February 28, 2024

Optimizing Fecal Occult Blood Test (FOBT) Colorectal Cancer Screening Using Gut Bacteriome as a Biomarker.

Optimizing Fecal Occult Blood Test (FOBT) Colorectal Cancer Screening Using Gut Bacteriome as a Biomarker.

Journal: Clinical colorectal cancer

Published: June 21, 2023

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review.

The Therapeutic Value of Solanum Steroidal (Glyco)Alkaloids: A 10-Year Comprehensive Review.

Journal: Molecules (Basel, Switzerland)

Published: May 10, 2023

Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management.

Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management.

Journal: Journal of peptide science : an official publication of the European Peptide Society

Published: November 14, 2022

Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.

Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.

Journal: ACS pharmacology & translational science

Published: November 10, 2022

Showing 1-12 of 15

Last Updated: 09/26/2026