Last Updated: 09/26/2026
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Found 9 publications
Optimization of α-Fluoro, β-Heteroaryl Acrylamide Warheads for KRASG12C Active-State Inhibition.
Journal: Journal of medicinal chemistry
Published: March 02, 2026
Optimization of Covalent Warhead Trajectory for KRASG12C Active-State Inhibition.
Journal: Journal of medicinal chemistry
Published: March 02, 2026
Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C.
Journal: Nature communications
Published: March 03, 2025
NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test.
Journal: Neuropharmacology
Published: February 25, 2013
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
Journal: Bioorganic & medicinal chemistry letters
Published: October 26, 2012
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: July 31, 2012
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.
Journal: Bioorganic & medicinal chemistry letters
Published: June 26, 2012
Amino-caprolactam derivatives as gamma-secretase inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: July 24, 2007
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: May 02, 2007
Showing 1-9 of 9
Last Updated: 09/26/2026