Last Updated: 09/26/2026
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Found 12 publications
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention.
Journal: Journal of medicinal chemistry
Published: December 23, 2024
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Journal: Journal of medicinal chemistry
Published: April 20, 2021
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.
Journal: Journal of medicinal chemistry
Published: February 23, 2021
1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity.
Journal: Journal of medicinal chemistry
Published: December 22, 2020
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
Journal: Journal of medicinal chemistry
Published: April 07, 2020
Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.
Journal: Journal of medicinal chemistry
Published: March 16, 2019
Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development.
Journal: Journal of medicinal chemistry
Published: December 21, 2018
Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.
Journal: Journal of medicinal chemistry
Published: November 08, 2018
Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.
Journal: Parasites & vectors
Published: April 21, 2017
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus.
Journal: Parasites & vectors
Published: April 14, 2017
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
Journal: ACS infectious diseases
Published: September 20, 2016
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Journal: Nature communications
Published: September 02, 2016
Showing 1-12 of 12
Last Updated: 09/26/2026