Michael J. Gait

Francis Crick Avenue
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 47 publications

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model.

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model.

Journal: RSC chemical biology
Published: December 15, 2024

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation.

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation.

Journal: Cells
Published: July 31, 2023

Introduction and History of the Chemistry of Nucleic Acids Therapeutics.

Introduction and History of the Chemistry of Nucleic Acids Therapeutics.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: February 25, 2022

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy.

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy.

Journal: JCI insight
Published: August 18, 2021

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.

Journal: Nucleic acid therapeutics
Published: February 10, 2021

Dystrophin involvement in peripheral circadian SRF signalling.

Dystrophin involvement in peripheral circadian SRF signalling.

Journal: Life science alliance
Published: January 07, 2021

Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy.

Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: August 15, 2019

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice.

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice.

Journal: The Journal of clinical investigation
Published: February 15, 2019

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment.

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment.

Journal: Nucleic acid therapeutics
Published: October 12, 2018

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment.

Journal: Human molecular genetics
Published: July 26, 2018

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs.

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs.

Journal: Frontiers in chemistry
Published: August 15, 2017

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives.

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives.

Journal: Interface focus
Published: April 07, 2017
Showing 1-12 of 47

Last Updated: 09/26/2026