Last Updated: 09/26/2026
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Found 28 publications
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C.
Journal: Journal of medicinal chemistry
Published: March 02, 2026
Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases.
Journal: Journal of medicinal chemistry
Published: October 30, 2025
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
Journal: ACS medicinal chemistry letters
Published: July 02, 2024
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
Journal: Journal of medicinal chemistry
Published: November 15, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
Journal: Journal of medicinal chemistry
Published: March 29, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
Journal: ACS medicinal chemistry letters
Published: January 27, 2021
Bacterial Endocarditis Following Deep Enteroscopy: Is Prophylaxis Warranted?
Journal: ACG case reports journal
Published: February 09, 2019
Common Antacid Medication-Ranitidine Causing a Rare Serious Adverse Effect.
Journal: Cureus
Published: January 19, 2019
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Journal: Bioorganic & medicinal chemistry letters
Published: November 11, 2018
Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.
Journal: Journal of medicinal chemistry
Published: June 05, 2018
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Journal: Journal of medicinal chemistry
Published: September 21, 2017
Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: November 17, 2016
Last Updated: 09/26/2026