Michael Willem

Munich, BY 81377, Germany

Last Updated: 09/26/2026

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Found 58 publications

Tracking of Neuroinflammation Dynamics During Combined Anti-β-Amyloid Therapy (AAT) and Immunomodulation in a Preclinical Alzheimer's Disease Model.

Tracking of Neuroinflammation Dynamics During Combined Anti-β-Amyloid Therapy (AAT) and Immunomodulation in a Preclinical Alzheimer's Disease Model.

Journal: International journal of molecular sciences

Published: April 04, 2026

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: March 02, 2026

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency.

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency.

Journal: bioRxiv : the preprint server for biology

Published: November 24, 2025

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

Journal: Acta neuropathologica

Published: November 24, 2025

Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain.

Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain.

Journal: Journal of medicinal chemistry

Published: July 25, 2025

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

Journal: Molecular neurodegeneration

Published: March 28, 2025

Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction.

Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Published: January 07, 2025

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Journal: Immunity

Published: December 05, 2024

The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis.

The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis.

Journal: Life science alliance

Published: October 09, 2024

Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Journal: Nature neuroscience

Published: August 14, 2024

PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies.

PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies.

Journal: Theranostics

Published: April 09, 2024

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: February 20, 2024

Showing 1-12 of 58

Last Updated: 09/26/2026