Michele Tonelli

Genoa, 16132, Italy

Last Updated: 09/26/2026

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Found 56 publications

Cycloguanil Revisited: A Legacy Antifolate as a Template for Modern Medicinal Chemistry.

Cycloguanil Revisited: A Legacy Antifolate as a Template for Modern Medicinal Chemistry.

Journal: Current medicinal chemistry

Published: January 18, 2026

Assessing the Multitarget Therapeutic Potential of Novel 9-Aminoacridine Derivatives for Alzheimer's Disease.

Assessing the Multitarget Therapeutic Potential of Novel 9-Aminoacridine Derivatives for Alzheimer's Disease.

Journal: ACS chemical neuroscience

Published: January 09, 2026

Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents.

Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents.

Journal: Bioorganic chemistry

Published: January 17, 2025

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors.

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: November 07, 2024

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents.

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents.

Journal: ACS infectious diseases

Published: July 02, 2024

Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling.

Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling.

Journal: Molecules (Basel, Switzerland)

Published: February 16, 2024

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.

Journal: Journal of medicinal chemistry

Published: November 03, 2023

Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays.

Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: October 16, 2023

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.

Journal: European journal of medicinal chemistry

Published: September 11, 2023

Further Quinolizidine Derivatives as Antiarrhythmic Agents- 3.

Further Quinolizidine Derivatives as Antiarrhythmic Agents- 3.

Journal: Molecules (Basel, Switzerland)

Published: August 09, 2023

Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays.

Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 28, 2023

State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis.

State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis.

Journal: Current medicinal chemistry

Published: May 09, 2023

Showing 1-12 of 56

Last Updated: 09/26/2026