Mike Tyers

Mount Sinai Hospital
Canada

Last Updated: 09/26/2026

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Found 104 publications

The scaffold protein PRR14L is linked to mitotic fidelity and sensitivity to MPS1 inhibition.

The scaffold protein PRR14L is linked to mitotic fidelity and sensitivity to MPS1 inhibition.

Journal: Molecular biology of the cell

Published: May 20, 2026

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.

Journal: eLife

Published: May 15, 2026

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

Journal: eLife

Published: May 05, 2026

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Journal: bioRxiv : the preprint server for biology

Published: February 09, 2026

CRISPR Screen Uncovers SLC26A2 as a Modulator of Tungsten Toxicity in Endochondral Ossification.

CRISPR Screen Uncovers SLC26A2 as a Modulator of Tungsten Toxicity in Endochondral Ossification.

Journal: Environmental research

Published: December 26, 2025

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Journal: Communications chemistry

Published: December 17, 2025

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.

Journal: bioRxiv : the preprint server for biology

Published: November 24, 2025

De novo design of potent inhibitors of clostridial family toxins.

De novo design of potent inhibitors of clostridial family toxins.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: September 22, 2025

A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.

A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.

Journal: Disease models & mechanisms

Published: August 19, 2025

Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.

Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.

Journal: Frontiers in neuroscience

Published: May 15, 2025

Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.

Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice.

Journal: Scientific reports

Published: March 11, 2025

A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.

A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.

Journal: Bioconjugate chemistry

Published: August 21, 2024

Showing 1-12 of 104

Last Updated: 09/26/2026