Misaki Sekiguchi

Wako, Japan

Last Updated: 09/26/2026

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Found 14 publications

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain.

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain.

Journal: Journal of Alzheimer's disease : JAD

Published: November 19, 2025

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: November 11, 2024

Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice.

Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice.

Journal: eNeuro

Published: June 12, 2024

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Journal: Life science alliance

Published: February 08, 2024

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: February 01, 2024

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Journal: Science advances

Published: June 08, 2022

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.

Journal: Acta neuropathologica communications

Published: March 10, 2022

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

Journal: The Journal of biological chemistry

Published: June 11, 2021

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

Journal: Journal of Alzheimer's disease : JAD

Published: April 14, 2020

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Journal: Nature communications

Published: January 27, 2018

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Journal: Proteomics

Published: May 13, 2014

Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.

Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.

Journal: The American journal of pathology

Published: April 13, 2014

Showing 1-12 of 14

Last Updated: 09/26/2026