Mitchell J. Mumby

London, ON, Canada

Last Updated: 09/26/2026

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Found 9 publications

Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses.

Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses.

Journal: Journal of virology

Published: December 02, 2025

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women.

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women.

Journal: Journal of virology

Published: June 24, 2025

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women.

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women.

Journal: bioRxiv : the preprint server for biology

Published: November 18, 2024

Association between HIV-1 Nef-mediated MHC-I downregulation and the maintenance of the replication-competent latent viral reservoir in individuals with virally suppressed HIV-1 in Uganda: an exploratory cohort study.

Association between HIV-1 Nef-mediated MHC-I downregulation and the maintenance of the replication-competent latent viral reservoir in individuals with virally suppressed HIV-1 in Uganda: an exploratory cohort study.

Journal: The Lancet. Microbe

Published: January 22, 2024

Phylogenetic Reconstruction and Functional Characterization of the Ancestral Nef Protein of Primate Lentiviruses.

Phylogenetic Reconstruction and Functional Characterization of the Ancestral Nef Protein of Primate Lentiviruses.

Journal: Molecular biology and evolution

Published: July 18, 2023

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.

Journal: Journal of virology

Published: May 26, 2021

The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells.

The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells.

Journal: The Journal of biological chemistry

Published: April 07, 2021

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells.

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells.

Journal: Journal of virology

Published: November 29, 2019

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.

Journal: mBio

Published: June 20, 2019

Showing 1-9 of 9

Last Updated: 09/26/2026