Mitko Dimitrov

Lausanne, VD 1015, Switzerland

Last Updated: 09/26/2026

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Found 13 publications

The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.

The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.

Journal: Acta neuropathologica

Published: June 06, 2018

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Journal: The Journal of biological chemistry

Published: August 17, 2016

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.

Journal: Scientific reports

Published: June 22, 2016

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.

Journal: Nature communications

Published: April 01, 2016

Production of active glycosylation-deficient γ-secretase complex for crystallization studies.

Production of active glycosylation-deficient γ-secretase complex for crystallization studies.

Journal: Biotechnology and bioengineering

Published: February 11, 2015

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.

Journal: Human molecular genetics

Published: September 03, 2014

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

Journal: Journal of neurochemistry

Published: August 29, 2014

Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.

Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.

Journal: The Journal of biological chemistry

Published: January 29, 2014

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.

Journal: Nature communications

Published: December 13, 2012

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

Journal: The Journal of biological chemistry

Published: December 05, 2012

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy.

Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: October 19, 2012

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.

Journal: Biochemistry

Published: October 17, 2012

Showing 1-12 of 13

Last Updated: 09/26/2026