Mitsunori Kono

Fujisawa, 2518555, Japan

Last Updated: 09/26/2026

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Found 12 publications

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists.

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists.

Journal: ChemMedChem

Published: July 12, 2019

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.

Journal: Journal of medicinal chemistry

Published: January 18, 2019

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.

Journal: Journal of medicinal chemistry

Published: March 07, 2018

Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist.

Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist.

Journal: Pharmacology

Published: January 25, 2018

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist.

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist.

Journal: Biochemical pharmacology

Published: November 14, 2017

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

Journal: Bioorganic & medicinal chemistry

Published: October 11, 2017

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry

Published: October 11, 2017

Identification of novel quinazolinedione derivatives as RORγt inverse agonist.

Identification of novel quinazolinedione derivatives as RORγt inverse agonist.

Journal: Bioorganic & medicinal chemistry

Published: October 09, 2017

Discovery of a 7-arylaminobenzimidazole series as novel CRF1 receptor antagonists.

Discovery of a 7-arylaminobenzimidazole series as novel CRF1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry

Published: June 08, 2016

Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52.

Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52.

Journal: Journal of medicinal chemistry

Published: June 03, 2014

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: November 01, 2013

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: October 05, 2012

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Last Updated: 09/26/2026