Mizuho Une

Kure, 7370112, Japan

Last Updated: 09/26/2026

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Found 14 publications

FLG249 Exhibits FXR Antagonist Activity by Inducing Dissociation of Both Corepressors and Coactivators from FXR.

FLG249 Exhibits FXR Antagonist Activity by Inducing Dissociation of Both Corepressors and Coactivators from FXR.

Journal: Biological & pharmaceutical bulletin

Published: July 16, 2025

Fecal fatty acid-linked bile acid profiles in pediatric patients with ulcerative colitis.

Fecal fatty acid-linked bile acid profiles in pediatric patients with ulcerative colitis.

Journal: Clinica chimica acta; international journal of clinical chemistry

Published: October 08, 2024

FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice.

FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice.

Journal: Biological & pharmaceutical bulletin

Published: August 13, 2024

Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 binding to the preS1 region.

Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 binding to the preS1 region.

Journal: Antiviral research

Published: August 06, 2024

Discovery of FXR/PPARγ dual partial agonist.

Discovery of FXR/PPARγ dual partial agonist.

Journal: Bioorganic & medicinal chemistry

Published: February 03, 2023

Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels.

Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels.

Journal: Biological & pharmaceutical bulletin

Published: October 02, 2022

Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum.

Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum.

Journal: ACS medicinal chemistry letters

Published: December 06, 2020

Dual Agonist of Farnesoid X Receptor and Takeda G Protein-Coupled Receptor 5 Inhibits Hepatitis B Virus Infection In Vitro and In Vivo.

Dual Agonist of Farnesoid X Receptor and Takeda G Protein-Coupled Receptor 5 Inhibits Hepatitis B Virus Infection In Vitro and In Vivo.

Journal: Hepatology (Baltimore, Md.)

Published: June 12, 2020

N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR).

N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR).

Journal: Bioorganic & medicinal chemistry

Published: March 26, 2020

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

Journal: Bioorganic & medicinal chemistry

Published: March 05, 2019

Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.

Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.

Journal: Internal medicine (Tokyo, Japan)

Published: February 13, 2018

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.

Journal: ACS medicinal chemistry letters

Published: September 03, 2017

Showing 1-12 of 14

Last Updated: 09/26/2026