Mohamed Kreir

Janssen R&D
Beerse, VLG, Belgium

Last Updated: 09/26/2026

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Found 24 publications

Detection of seizurogenic compounds in human and rat neurons in vitro: A multi-laboratory, multi-model assessment.

Detection of seizurogenic compounds in human and rat neurons in vitro: A multi-laboratory, multi-model assessment.

Journal: Neurotoxicology

Published: April 27, 2026

From surplus to scientific value: Repurposing vascular tissues for organ bath standardization to de-risk vasoactive liabilities.

From surplus to scientific value: Repurposing vascular tissues for organ bath standardization to de-risk vasoactive liabilities.

Journal: Journal of pharmacological and toxicological methods

Published: March 02, 2026

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: November 24, 2023

Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery.

Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery.

Journal: Frontiers in pharmacology

Published: October 06, 2023

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.

Journal: Biomolecules

Published: August 10, 2023

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).

Journal: Frontiers in pharmacology

Published: May 27, 2023

High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures.

High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures.

Journal: Cells

Published: February 03, 2023

Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?

Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?

Journal: European journal of pharmacology

Published: March 08, 2022

Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Journal: Frontiers in physiology

Published: December 17, 2021

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.

Journal: Nature communications

Published: October 08, 2021

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.

Journal: Stem cell reviews and reports

Published: April 29, 2021

Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model.

Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model.

Journal: Journal of pharmacological and toxicological methods

Published: February 18, 2021

Showing 1-12 of 24

Last Updated: 09/26/2026