Nadezhda S. Dyrkheeva

Pirogov St, 2
Novosibirsk, NVS 630090, Russian Federation

Last Updated: 09/26/2026

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Found 54 publications

The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells.

The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells.

Journal: Current issues in molecular biology

Published: February 21, 2026

Special Issue "New Agents and Novel Drugs Use for the Oncological Diseases Treatment".

Special Issue "New Agents and Novel Drugs Use for the Oncological Diseases Treatment".

Journal: International journal of molecular sciences

Published: November 27, 2025

Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells.

Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells.

Journal: International journal of molecular sciences

Published: September 20, 2025

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2.

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2.

Journal: Vavilovskii zhurnal genetiki i selektsii

Published: August 07, 2025

Transcriptomic Analysis of TDP1-Knockout HEK293A Cells Treated with the TDP1 Inhibitor (Usnic Acid Derivative).

Transcriptomic Analysis of TDP1-Knockout HEK293A Cells Treated with the TDP1 Inhibitor (Usnic Acid Derivative).

Journal: International journal of molecular sciences

Published: August 01, 2025

Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animals.

Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animals.

Journal: Journal of pharmaceutical and biomedical analysis

Published: April 19, 2025

Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan

Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan

Journal: Molekuliarnaia biologiia

Published: March 03, 2025

Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair.

Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair.

Journal: Biomedicines

Published: October 23, 2024

Novel Peptide-Drug Conjugates with Dual Anticancer Activity.

Novel Peptide-Drug Conjugates with Dual Anticancer Activity.

Journal: International journal of molecular sciences

Published: October 17, 2024

Design, synthesis, and evaluation of dehydroabietyl imidazolidine-2,4-diones, 2,4,5-triones, and 2-thioxoimidazolidine-4,5-diones as TDP1 inhibitors and dual TDP1/TDP2 inhibitors.

Design, synthesis, and evaluation of dehydroabietyl imidazolidine-2,4-diones, 2,4,5-triones, and 2-thioxoimidazolidine-4,5-diones as TDP1 inhibitors and dual TDP1/TDP2 inhibitors.

Journal: Archiv der Pharmazie

Published: October 10, 2024

Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA-protein crosslink with apurinic/apyrimidinic site in cellular extracts.

Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA-protein crosslink with apurinic/apyrimidinic site in cellular extracts.

Journal: IUBMB life

Published: March 05, 2024

Transcriptomic analysis of HEK293A cells with a CRISPR/Cas9-mediated TDP1 knockout.

Transcriptomic analysis of HEK293A cells with a CRISPR/Cas9-mediated TDP1 knockout.

Journal: Biochimica et biophysica acta. General subjects

Published: December 25, 2023

Showing 1-12 of 54

Last Updated: 09/26/2026