Najma Rachidi

Institut Pasteur And INSERM U1201 F-75015 Paris France
Paris, 75015, France

Last Updated: 09/26/2026

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Found 21 publications

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy.

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy.

Journal: RSC medicinal chemistry

Published: March 25, 2025

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition.

Journal: ChemMedChem

Published: October 29, 2024

Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies.

Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies.

Journal: Frontiers in cellular and infection microbiology

Published: November 30, 2021

Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.

Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay.

Journal: Frontiers in cell and developmental biology

Published: October 22, 2021

Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.

Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion.

Journal: Frontiers in cellular and infection microbiology

Published: January 19, 2021

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Journal: European journal of medicinal chemistry

Published: September 04, 2020

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.

SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani.

Journal: Journal of proteomics

Published: June 24, 2019

The kinase domain of CK1δ can be phosphorylated by Chk1.

The kinase domain of CK1δ can be phosphorylated by Chk1.

Journal: Bioscience, biotechnology, and biochemistry

Published: May 17, 2019

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Journal: Gene

Published: April 30, 2019

CRISPR in Parasitology: Not Exactly Cut and Dried!

CRISPR in Parasitology: Not Exactly Cut and Dried!

Journal: Trends in parasitology

Published: February 08, 2019

Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.

Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.

Journal: Scientific reports

Published: November 19, 2018

Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit.

Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit.

Journal: BioMed research international

Published: July 14, 2017

Showing 1-12 of 21

Last Updated: 09/26/2026