Naoki Toyooka

Sugitani, 9300194, Japan

Last Updated: 09/26/2026

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Found 78 publications

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

Journal: Organic & biomolecular chemistry

Published: July 31, 2026

Involvement of Cav3.2 T-Type Ca2+ Channels and the Role of Endogenous Estrogen in Pruritus: Evidence from a Fundamental Study and Cross-Sectional Analysis of Pharmacy Claims Data.

Involvement of Cav3.2 T-Type Ca2+ Channels and the Role of Endogenous Estrogen in Pruritus: Evidence from a Fundamental Study and Cross-Sectional Analysis of Pharmacy Claims Data.

Journal: Biological & pharmaceutical bulletin

Published: March 15, 2026

Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells.

Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells.

Journal: European journal of medicinal chemistry

Published: December 10, 2025

Acute toxicity of frog-skin-homologous synthetic alkaloids and frog-skin extracts: miniaturized test to evaluate toxicity with Daphnia magna.

Acute toxicity of frog-skin-homologous synthetic alkaloids and frog-skin extracts: miniaturized test to evaluate toxicity with Daphnia magna.

Journal: Toxicon : official journal of the International Society on Toxinology

Published: June 08, 2025

Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors.

Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors.

Journal: Journal of medicinal chemistry

Published: January 06, 2025

HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice.

HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice.

Journal: European journal of pharmacology

Published: October 31, 2024

Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis.

Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis.

Journal: Journal of natural products

Published: October 27, 2024

Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor.

Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor.

Journal: European journal of medicinal chemistry

Published: August 07, 2024

Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations.

Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations.

Journal: Journal of medicinal chemistry

Published: August 06, 2024

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner.

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner.

Journal: Cells

Published: July 23, 2024

Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice.

Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice.

Journal: The journal of pain

Published: June 28, 2024

Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models.

Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models.

Journal: Molecular psychiatry

Published: June 17, 2024

Showing 1-12 of 78

Last Updated: 09/26/2026