Overview
The Chen laboratory studies how cancer and its immune microenvironment sense and respond to stresses and therapeutic insults to evade immune surveillance and develop drug resistance. We specialize in ER stress, Unfolded Protein Response (UPR), immunology, cancer biology, biochemistry, transgenic and preclinical animal models. Our research aims to elucidate the significance and mechanisms of stress responses in therapy resistance and anti-tumor immunity, and develop mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease (Nat Rev Cancer, 2021). Our study published in JCI revealed a critical role of the IRE1a/XBP1 branch of the UPR in mediating chemotherapy resistance and led to the first-in-human clinical trial of IRE1a RNase inhibitor. Our efforts in understanding proteostasis regulation revealed the direct cross-talk between oncogenic signaling and the protein quality control machinery and uncovered the mechanisms that account for the proteostasis rewiring in response to KRAS inhibition, allowing the drug-resistant cells to escape oncogenic KRAS addiction and gain resistance (Science, 2023). Another research area of the Chen laboratory focuses on ER Associated Degradation (ERAD). We recently discovered the crosstalk between ERAD complex and UPR in maintaining proteostasis and niche interactions (Nat Cell Biol, 2020, eLife, 2021).
Dr. Chen is board certified in Board Certification - Internal MedicineAmerican Board Of Internal MedicineBoard Certification - Hematology And Medical OncologyAmerican Board Of Internal Medicine. She is actively involved in clinical research, co-authoring 5 peer reviewed articles. Dr. Chen is currently accepting new patients.
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Insurance
Accepted insurance can change. Please verify directly with the provider.
Accepted insurance plans:
- EPO
- HMO
- POS
- PPO
- EPO
- HMO
- PPO
- HMO
- MANAGED MEDICAID PLAN
- MEDICARE SNP
- HMO
- INSURANCE PLAN
- MANAGED MEDICAID PLAN
- MEDICARE MAPD
- MEDICARE PDP
- MEDICARE SNP
- OTHER COMMERCIAL
- OTHER MEDICARE
- OTHER MEDICARE PART D
- PPO
- HMO
- INDEMNITY
- POS
- PPO
- OTHER MANAGED MEDICAID
- MANAGED MEDICAID PLAN
- MEDICARE-MEDICAID PLAN
- OTHER COMMERCIAL
- EPO
- HMO
- POS
- PPO
- EPO
- HMO
- INSURANCE PLAN
- MANAGED MEDICAID PLAN
- MEDICARE MAPD
- MEDICARE PDP
- MEDICARE SNP
- MEDICARE-MEDICAID PLAN
- OTHER MEDICARE
- OTHER MEDICARE PART D
Locations
2525 A Holly Hall St, Houston, TX 77054
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
Office
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Frequently Asked Questions about Dr. Natalie Chen
How do I make an appointment with Dr. Natalie Chen?
You can book an appointment with Dr. Natalie Chen by calling their office at 713-526-4243. MediFind provides direct contact information so you can schedule visits, second opinions, or consultations without navigating third-party calendars.
Does Dr. Natalie Chen accept my insurance?
Dr. Natalie Chen accepts most major insurance plans, including Aetna and Cigna. We recommend calling the office directly at 713-526-4243 to verify that your specific plan is currently accepted before your visit.
Areas of Expertise
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