Nicholas D. Lakin

South Parks Road
Oxford, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 18 publications

Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation.

Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation.

Journal: FEBS letters

Published: December 19, 2025

G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.

G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.

Journal: Nature communications

Published: June 19, 2025

Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.

Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.

Journal: Nature communications

Published: November 27, 2023

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity.

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity.

Journal: Nucleic acids research

Published: September 22, 2023

C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.

C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.

Journal: Nature communications

Published: February 06, 2023

Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3.

Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3.

Journal: Nature communications

Published: July 07, 2022

Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair.

Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair.

Journal: Frontiers in cell and developmental biology

Published: August 02, 2021

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones.

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones.

Journal: Nature communications

Published: March 05, 2021

Dictyostelium as a Model to Assess Site-Specific ADP-Ribosylation Events.

Dictyostelium as a Model to Assess Site-Specific ADP-Ribosylation Events.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: August 12, 2018

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Journal: Nature communications

Published: August 21, 2017

Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium.

Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium.

Journal: Nucleic acids research

Published: April 10, 2017

Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks.

Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks.

Journal: Scientific reports

Published: November 15, 2016

Showing 1-12 of 18

Last Updated: 09/26/2026