Last Updated: 09/26/2026
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Found 8 publications
Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia.
Journal: Science translational medicine
Published: August 19, 2026
Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia.
Journal: Neurobiology of disease
Published: June 21, 2025
TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency.
Journal: Scientific reports
Published: April 04, 2025
Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Published: October 24, 2023
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
Journal: Acta neuropathologica communications
Published: April 20, 2023
Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Published: January 20, 2023
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
Journal: Acta neuropathologica communications
Published: October 28, 2019
Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
Journal: Neurobiology of disease
Published: October 09, 2018
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Last Updated: 09/26/2026