Nicholas S. O'brien

University Drive
Callaghan, NSW 2308, Australia

Last Updated: 09/26/2026

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Found 13 publications

Sulfonadyn Compounds: A Class of Aryl Sulfonamides That Inhibit Dynamin GTPase and Clathrin-Mediated Endocytosis and Are Antiepileptic in Animal Models.

Sulfonadyn Compounds: A Class of Aryl Sulfonamides That Inhibit Dynamin GTPase and Clathrin-Mediated Endocytosis and Are Antiepileptic in Animal Models.

Journal: ACS chemical biology

Published: June 18, 2026

DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones.

DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones.

Journal: European journal of medicinal chemistry

Published: January 15, 2026

Twenty years of quinazolines as tubulin polymerisation inhibitors.

Twenty years of quinazolines as tubulin polymerisation inhibitors.

Journal: RSC medicinal chemistry

Published: November 20, 2025

From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects.

From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects.

Journal: RSC medicinal chemistry

Published: October 10, 2025

Substituted Benzylidene-3-Oxo-3,4-Dihydro-2H-Benzo[b][1,4]thiazine-6-Carboxylic Acid Analogs as Dynamin GTPase Inhibitors.

Substituted Benzylidene-3-Oxo-3,4-Dihydro-2H-Benzo[b][1,4]thiazine-6-Carboxylic Acid Analogs as Dynamin GTPase Inhibitors.

Journal: ChemMedChem

Published: May 11, 2025

Quinoline- and Pyrimidine-based Allosteric Modulators of the Sarco/Endoplasmic Reticulum Calcium ATPase.

Quinoline- and Pyrimidine-based Allosteric Modulators of the Sarco/Endoplasmic Reticulum Calcium ATPase.

Journal: ChemMedChem

Published: September 26, 2024

Next-generation of BBQ analogues that selectively target breast cancer.

Next-generation of BBQ analogues that selectively target breast cancer.

Journal: Frontiers in chemistry

Published: March 05, 2024

2,3-Dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation.

2,3-Dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation.

Journal: RSC medicinal chemistry

Published: October 25, 2023

Direct-acting antiviral therapies for hepatitis C infection: global registration, reimbursement, and restrictions.

Direct-acting antiviral therapies for hepatitis C infection: global registration, reimbursement, and restrictions.

Journal: The lancet. Gastroenterology & hepatology

Published: August 18, 2023

Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes.

Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: January 31, 2022

Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors.

Synthesis of Phthaladyn-29 and Naphthalimide-10, GTP Site Directed Dynamin GTPase Inhibitors.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: January 31, 2022

Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases.

Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases.

Journal: Frontiers in cellular neuroscience

Published: August 05, 2021

Showing 1-12 of 13

Last Updated: 09/26/2026