Nicky J. Willis

Gower Street, U.K
London, ENG WC1E6BT, United Kingdom

Last Updated: 09/26/2026

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Found 20 publications

Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.

Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.

Journal: European journal of medicinal chemistry

Published: December 08, 2022

Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1H-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step.

Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1H-1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step.

Journal: RSC advances

Published: August 16, 2022

Structural Analysis and Development of Notum Fragment Screening Hits.

Structural Analysis and Development of Notum Fragment Screening Hits.

Journal: ACS chemical neuroscience

Published: June 22, 2022

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal: Journal of medicinal chemistry

Published: May 10, 2022

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.

Journal: Bioorganic & medicinal chemistry

Published: April 04, 2022

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

Journal: Journal of medicinal chemistry

Published: December 23, 2021

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Journal: ACS infectious diseases

Published: April 02, 2021

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Journal: Journal of medicinal chemistry

Published: March 30, 2021

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Journal: European journal of medicinal chemistry

Published: December 01, 2020

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

Journal: Journal of medicinal chemistry

Published: October 30, 2020

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Journal: Journal of medicinal chemistry

Published: August 14, 2020

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Journal: Nature

Published: March 05, 2020

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Last Updated: 09/26/2026