Niklas Jansch

Darmstadt, HE 64295, Germany

Last Updated: 09/26/2026

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Found 13 publications

Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.

Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 19, 2023

Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors.

Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors.

Journal: International journal of molecular sciences

Published: September 13, 2022

3-Chloro-5-Substituted-1,2,4-Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers.

3-Chloro-5-Substituted-1,2,4-Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers.

Journal: Chembiochem : a European journal of chemical biology

Published: July 21, 2022

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4.

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: September 06, 2021

Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.

Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.

Journal: Chembiochem : a European journal of chemical biology

Published: October 08, 2020

Switching the Switch: Ligand Induced Disulfide Formation in HDAC8.

Switching the Switch: Ligand Induced Disulfide Formation in HDAC8.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: April 08, 2020

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation.

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation.

Journal: Bioorganic chemistry

Published: March 31, 2020

Discovery of 5-naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines.

Discovery of 5-naphthylidene-2,4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines.

Journal: Bioorganic chemistry

Published: October 02, 2019

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction.

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction.

Journal: Organic letters

Published: September 10, 2019

Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.

Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.

Journal: European journal of medicinal chemistry

Published: July 10, 2019

Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.

Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.

Journal: Biochimica et biophysica acta. General subjects

Published: August 31, 2018

Kinetically selective and potent inhibitors of HDAC8.

Kinetically selective and potent inhibitors of HDAC8.

Journal: Biological chemistry

Published: August 31, 2018

Showing 1-12 of 13

Last Updated: 09/26/2026