Nikolas Gunkel

Heidelberg, BW, Germany

Last Updated: 09/26/2026

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Found 17 publications

TR-FRET assay for profiling HDAC10 inhibitors and PROTACs.

TR-FRET assay for profiling HDAC10 inhibitors and PROTACs.

Journal: Methods in enzymology

Published: May 17, 2025

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy.

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy.

Journal: Nature communications

Published: October 23, 2024

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs.

Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs.

Journal: Redox biology

Published: November 08, 2022

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.

Journal: Chembiochem : a European journal of chemical biology

Published: April 01, 2022

Real-world evidence for preventive effects of statins on cancer incidence: A trans-Atlantic analysis.

Real-world evidence for preventive effects of statins on cancer incidence: A trans-Atlantic analysis.

Journal: Clinical and translational medicine

Published: December 02, 2021

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.

Journal: Blood

Published: July 30, 2021

Inclusion Complexes of Gold(I)-Dithiocarbamates with β-Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery.

Inclusion Complexes of Gold(I)-Dithiocarbamates with β-Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: April 15, 2021

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.

Journal: ChemMedChem

Published: March 06, 2020

Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6.

Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6.

Journal: ChemMedChem

Published: September 19, 2019

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.

Journal: Journal of medicinal chemistry

Published: April 10, 2019

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity.

Journal: Journal of medicinal chemistry

Published: September 14, 2018

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.

Journal: Archives of toxicology

Published: February 22, 2018

Showing 1-12 of 17

Last Updated: 09/26/2026