Nobuhisa Iwata

Nagasaki, Japan

Last Updated: 09/26/2026

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Found 42 publications

Stepwise Upregulation of Microglial Genes through the Slow Progression of Amyloid Pathology in Alzheimer's Disease Model Mice.

Stepwise Upregulation of Microglial Genes through the Slow Progression of Amyloid Pathology in Alzheimer's Disease Model Mice.

Journal: Biological & pharmaceutical bulletin

Published: September 02, 2026

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Journal: Experimental neurology

Published: April 20, 2026

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain.

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain.

Journal: Journal of Alzheimer's disease : JAD

Published: November 19, 2025

Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells.

Cell type- and neuronal differentiation-dependent MME 5'UTR splice variants with distinct translational outputs in human cells.

Journal: Journal of biochemistry

Published: November 10, 2025

The tale of donanemab: God is in the details.

The tale of donanemab: God is in the details.

Journal: Journal of Alzheimer's disease : JAD

Published: September 03, 2025

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

Journal: The Journal of comparative neurology

Published: March 08, 2025

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: November 11, 2024

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.

Journal: Science signaling

Published: August 06, 2024

Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice.

Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice.

Journal: Neuropsychopharmacology reports

Published: June 29, 2024

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.

Journal: Biological & pharmaceutical bulletin

Published: February 25, 2024

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Journal: Life science alliance

Published: February 08, 2024

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Journal: Journal of biochemistry

Published: August 05, 2023

Showing 1-12 of 42

Last Updated: 09/26/2026