Nobutada Tanaka

Tokyo, 1088641, Japan

Last Updated: 09/26/2026

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Found 37 publications

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

Journal: Organic & biomolecular chemistry

Published: July 31, 2026

Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights.

Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic Insights.

Journal: Journal of medicinal chemistry

Published: May 06, 2026

Fragment mapping-guided virtual screening identifies a small-molecule modulator of NPM1 oligomerization.

Fragment mapping-guided virtual screening identifies a small-molecule modulator of NPM1 oligomerization.

Journal: Computational biology and chemistry

Published: April 27, 2026

Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells.

Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells.

Journal: European journal of medicinal chemistry

Published: December 10, 2025

Investigation of the functional hot-spot residues of an enzyme by real-time monitoring of the enzymatic reaction using NMR and computational approaches.

Investigation of the functional hot-spot residues of an enzyme by real-time monitoring of the enzymatic reaction using NMR and computational approaches.

Journal: Scientific reports

Published: July 04, 2025

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents.

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents.

Journal: Molecules (Basel, Switzerland)

Published: November 28, 2024

Expanding the Chemical Space of Reverse Fosmidomycin Analogs.

Expanding the Chemical Space of Reverse Fosmidomycin Analogs.

Journal: ACS medicinal chemistry letters

Published: October 17, 2024

CDK8 inhibitor KY-065 rescues skeletal abnormalities in achondroplasia model mice.

CDK8 inhibitor KY-065 rescues skeletal abnormalities in achondroplasia model mice.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: June 01, 2024

Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).

Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).

Journal: ACS infectious diseases

Published: April 22, 2024

The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets.

The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets.

Journal: Journal of biochemistry

Published: June 30, 2023

Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.

Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.

Journal: Journal of medicinal chemistry

Published: June 14, 2023

Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities.

Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: October 28, 2022

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Last Updated: 09/26/2026