Nobuyo Kuwata-Higashi
Shinjuku, 1628655, Japan
Last Updated: 09/26/2026
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Found 33 publications
Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands.
Journal: RSC medicinal chemistry
Published: April 20, 2026
Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity.
Journal: Journal of medicinal chemistry
Published: September 11, 2025
Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity.
Journal: Virus research
Published: May 23, 2025
An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier.
Journal: PNAS nexus
Published: July 15, 2024
Neutralization activity of HCWs' sera after Omicron XBB.1.5-adapted monovalent COVID-19 mRNA vaccination.
Journal: The Journal of infection
Published: January 19, 2024
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
Journal: European journal of medicinal chemistry
Published: December 06, 2023
Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement.
Journal: Chemical & pharmaceutical bulletin
Published: December 03, 2023
A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs.
Journal: Antiviral research
Published: November 29, 2023
Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties.
Journal: Journal of medicinal chemistry
Published: September 27, 2023
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.
Journal: Bioorganic & medicinal chemistry letters
Published: August 29, 2023
Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron.
Journal: Scientific reports
Published: August 05, 2023
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Journal: Science advances
Published: July 12, 2023
Last Updated: 09/26/2026